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Proceedings Paper

Clinical applications of image-based airway computational fluid dynamics: assessment of inhalation medication and endobronchial devices
Author(s): Jan W. De Backer; Wim G. Vos; Paul Germonpré; Rodrigo Salgado; Paul M. Parizel; Wilfried De Backer
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Paper Abstract

Computational fluid dynamics (CFD) is a technique that is used increasingly in the biomedical field. Solving the flow equations numerically provides a convenient way to assess the efficiency of therapies and devices, ranging from cardiovascular stents and heart valves to hemodialysis workflows. Also in the respiratory field CFD has gained increasing interest, especially through the combination of three dimensional image reconstruction which results in highend patient-specific models. This paper provides an overview of clinical applications of CFD through image based modeling, resulting from recent studies performed in our center. We focused on two applications: assessment of the efficiency of inhalation medication and analysis of endobronchial valve placement. In the first application we assessed the mode of action of a novel bronchodilator in 10 treated patients and 4 controls. We assessed the local volume increase and resistance change based on the combination of imaging and CFD. We found a good correlation between the changes in volume and resistance coming from the CFD results and the clinical tests. In the second application we assessed the placement and effect of one way endobronchial valves on respiratory function in 6 patients. We found a strong patientspecific result of the therapy where in some patients the therapy resulted in complete atelectasis of the target lobe while in others the lobe remained inflated. We concluded from these applications that CFD can provide a better insight into clinically relevant therapies.

Paper Details

Date Published: 27 February 2009
PDF: 9 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72621P (27 February 2009); doi: 10.1117/12.811476
Show Author Affiliations
Jan W. De Backer, Univ. Hospital Antwerp (Belgium)
Univ. of Antwerp (Belgium)
Wim G. Vos, Univ. Hospital Antwerp (Belgium)
Univ. of Antwerp (Belgium)
Paul Germonpré, Univ. Hospital Antwerp (Belgium)
Rodrigo Salgado, Univ. Hospital Antwerp (Belgium)
Paul M. Parizel, Univ. Hospital Antwerp (Belgium)
Wilfried De Backer, Univ. Hospital Antwerp (Belgium)

Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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