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Proceedings Paper • Open Access

Determination of cup-to-disc ratio of optical nerve head for diagnosis of glaucoma on stereo retinal fundus image pairs
Author(s): Chisako Muramatsu; Toshiaki Nakagawa; Akira Sawada; Yuji Hatanaka; Takeshi Hara; Tetsuya Yamamoto; Hiroshi Fujita

Paper Abstract

A large cup-to-disc (C/D) ratio, which is the ratio of the diameter of the depression (cup) to that of the optical nerve head (ONH, disc), can be one of the important signs for diagnosis of glaucoma. Eighty eyes, including 25 eyes with the signs of glaucoma, were imaged by a stereo retinal fundus camera. An ophthalmologist provided the outlines of cup and disc on a regular monitor and on the stereo display. The depth image of the ONH was created by determining the corresponding pixels in a pair of images based on the correlation coefficient in localized regions. The areas of the disc and cup were determined by use of the red component in one of the color images and by use of the depth image, respectively. The C/D ratio was determined based on the largest vertical lengths in the cup and disc areas, which was then compared with that by the ophthalmologist. The disc areas determined by the computerized method agreed relatively well with those determined by the ophthalmologist, whereas the agreement for the cup areas was somewhat lower. When C/D ratios were employed for distinction between the glaucomatous and non-glaucomatous eyes, the area under the receiver operating characteristic curve (AUC) was 0.83. The computerized analysis of ONH can be useful for diagnosis of glaucoma.

Paper Details

Date Published: 3 March 2009
PDF: 8 pages
Proc. SPIE 7260, Medical Imaging 2009: Computer-Aided Diagnosis, 72603L (3 March 2009); doi: 10.1117/12.811461
Show Author Affiliations
Chisako Muramatsu, Gifu Univ. (Japan)
Toshiaki Nakagawa, Kowa Co., Ltd. (Japan)
Akira Sawada, Gifu Univ. (Japan)
Yuji Hatanaka, Univ. of Shiga Prefecture (Japan)
Takeshi Hara, Gifu Univ. (Japan)
Tetsuya Yamamoto, Gifu Univ. (Japan)
Hiroshi Fujita, Gifu Univ. (Japan)

Published in SPIE Proceedings Vol. 7260:
Medical Imaging 2009: Computer-Aided Diagnosis
Nico Karssemeijer; Maryellen L. Giger, Editor(s)

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