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Proceedings Paper

3D registration of micro PET-CT for measurable correlates of dyspeptic symptoms in mice
Author(s): Jon Camp; Kathryn Simpson; Michael R. Bardsley; Laura N. Popko; David L. Young; Bradley J. Kemp; Val Lowe; Tamas Ordog; Richard Robb M.D.
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Paper Abstract

Patients with chronic calorie insufficiency commonly suffer from upper gastrointestinal dysfunction and consequent dyspeptic symptoms, which may interfere with their nutritional rehabilitation. To investigate the relationship between gastric dysfunction and feeding behavior, we exposed mice to chronic caloric restriction and demonstrated gastric motor abnormalities in them. Gastric dysmotility is typically associated with dyspeptic symptoms but sensations cannot be directly assessed in animal models. Therefore, as an initial step toward establishing measurable correlates of postprandial symptoms in small animals, we have attempted to characterize central responses to food intake by positron emission tomography-computerized microtomography (PET-CT) in normal and calorically restricted mice. Animals consumed a standard test meal after an overnight fast before receiving 2-deoxy-2[18F]fluoro-D-glucose tracer. The same mice were also scanned in the fasting state on a separate day. We were able to bring the fed and fasting PET volume images into spatial registration with each other and with an MR-derived atlas of the mouse brain, so that the differences in uptake between the two states could be mapped quantitatively against the neuroanatomic regions of the atlas. Our approach is suitable for studying the effects of gastric dysmotilities on central responses to feeding.

Paper Details

Date Published: 27 February 2009
PDF: 8 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72620Z (27 February 2009); doi: 10.1117/12.811408
Show Author Affiliations
Jon Camp, Mayo Clinic (United States)
Kathryn Simpson, Mayo Clinic (United States)
Michael R. Bardsley, Mayo Clinic (United States)
Laura N. Popko, Mayo Clinic (United States)
David L. Young, Mayo Clinic (United States)
Bradley J. Kemp, Mayo Clinic (United States)
Val Lowe, Mayo Clinic (United States)
Tamas Ordog, Mayo Clinic (United States)
Richard Robb M.D., Mayo Clinic (United States)

Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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