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Proceedings Paper

3D structural measurements of the proximal femur from 2D DXA images using a statistical atlas
Author(s): Omar M. Ahmad; Krishna Ramamurthi; Kevin E. Wilson; Klaus Engelke; Mary Bouxsein; Russell H. Taylor
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Paper Abstract

A method to obtain 3D structural measurements of the proximal femur from 2D DXA images and a statistical atlas is presented. A statistical atlas of a proximal femur was created consisting of both 3D shape and volumetric density information and then deformably registered to 2D fan-beam DXA images. After the registration process, a series of 3D structural measurements were taken on QCT-estimates generated by transforming the registered statistical atlas into a voxel volume. These measurements were compared to the equivalent measurements taken on the actual QCT (ground truth) associated with the DXA images for each of 20 human cadaveric femora. The methodology and results are presented to address the potential clinical feasibility of obtaining 3D structural measurements from limited angle DXA scans and a statistical atlas of the proximal femur in-vivo.

Paper Details

Date Published: 27 February 2009
PDF: 8 pages
Proc. SPIE 7260, Medical Imaging 2009: Computer-Aided Diagnosis, 726005 (27 February 2009); doi: 10.1117/12.811176
Show Author Affiliations
Omar M. Ahmad, The Johns Hopkins Univ. (United States)
Krishna Ramamurthi, Hologic, Inc. (United States)
Kevin E. Wilson, Hologic, Inc. (United States)
Klaus Engelke, Univ. Erlangen-Nürnberg (Germany)
Mary Bouxsein, Orthopaedic Biomechanics Lab., BIDMC (United States)
Russell H. Taylor, The Johns Hopkins Univ. (United States)

Published in SPIE Proceedings Vol. 7260:
Medical Imaging 2009: Computer-Aided Diagnosis
Nico Karssemeijer; Maryellen L. Giger, Editor(s)

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