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Proceedings Paper

Functional network connectivity analysis based on partial correlation in Alzheimer's disease
Author(s): Nan Zhang; Xiaoting Guan; Yumei Zhang; Jingjing Li; Hongyan Chen; Kewei Chen; Adam Fleisher; Li Yao; Xia Wu
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Paper Abstract

Functional network connectivity (FNC) measures the temporal dependency among the time courses of functional networks. However, the marginal correlation between two networks used in the classic FNC analysis approach doesn't separate the FNC from the direct/indirect effects of other networks. In this study, we proposed an alternative approach based on partial correlation to evaluate the FNC, since partial correlation based FNC can reveal the direct interaction between a pair of networks, removing dependencies or influences from others. Previous studies have demonstrated less task-specific activation and less rest-state activity in Alzheimer's disease (AD). We applied present approach to contrast FNC differences of resting state network (RSN) between AD and normal controls (NC). The fMRI data under resting condition were collected from 15 AD and 16 NC. FNC was calculated for each pair of six RSNs identified using Group ICA, thus resulting in 15 (2 out of 6) pairs for each subject. Partial correlation based FNC analysis indicated 6 pairs significant differences between groups, while marginal correlation only revealed 2 pairs (involved in the partial correlation results). Additionally, patients showed lower correlation than controls among most of the FNC differences. Our results provide new evidences for the disconnection hypothesis in AD.

Paper Details

Date Published: 27 February 2009
PDF: 12 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72621X (27 February 2009); doi: 10.1117/12.810909
Show Author Affiliations
Nan Zhang, Beijing Normal Univ. (China)
Xiaoting Guan, Beijing Tiantan Hospital (China)
Yumei Zhang, Beijing Tiantan Hospital (China)
Jingjing Li, Beijing Tiantan Hospital (China)
Hongyan Chen, Beijing Tiantan Hospital (China)
Kewei Chen, Banner Alzheimer's Institute (United States)
Adam Fleisher, Banner Alzheimer's Institute (United States)
Li Yao, Beijing Normal Univ. (China)
Xia Wu, Beijing Normal Univ. (China)

Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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