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Proceedings Paper

Protein profile study of clinical samples using laser induced fluorescence as the detection method: case of malignant and normal cervical tissues
Author(s): Gopal Karemore; Sujatha N. Raja; Lavanya Rai; V. B. Kartha; Santhosh Chidangil
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Paper Abstract

Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.

Paper Details

Date Published: 23 February 2009
PDF: 8 pages
Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691I (23 February 2009); doi: 10.1117/12.809972
Show Author Affiliations
Gopal Karemore, Univ. of Copenhagen (Denmark)
Nordic Bioscience A/S (Denmark)
Sujatha N. Raja, Manipal Univ. (India)
Lavanya Rai, Manipal Univ. (India)
V. B. Kartha, Manipal Univ. (India)
Santhosh Chidangil, Manipal Univ. (India)

Published in SPIE Proceedings Vol. 7169:
Advanced Biomedical and Clinical Diagnostic Systems VII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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