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Proceedings Paper

Visible and near infrared autofluorescence and hyperspectral imaging spectroscopy for the investigation of colorectal lesions and detection of exogenous fluorophores
Author(s): Kevin R. Koh; Tobias C. Wood; Robert D Goldin; Guang-Zhong Yang; Daniel S. Elson
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Paper Abstract

Colonoscopy is the most widely prescribed colonic imaging method for the clinical surveillance of colorectal cancer for the detection of adenomatous polyps. However, some adenomas appear diminutive and flat, making them difficult to discriminate from non-neoplastic tissue even for the most experienced colonoscopists. We report here an optical system for performing excitation resolved visible and near-infrared autofluorescence imaging and hyperspectral imaging for the accurate distinction between neoplastic and non-neoplastic tissue. This is demonstrated on ex vivo colorectal tissues using our multimodal imaging system, which has potential applications for the in vivo endoscopic imaging and diagnosis of colorectal cancer tissue.

Paper Details

Date Published: 23 February 2009
PDF: 8 pages
Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691E (23 February 2009); doi: 10.1117/12.809313
Show Author Affiliations
Kevin R. Koh, Imperial College London (United Kingdom)
Tobias C. Wood, Imperial College London (United Kingdom)
Robert D Goldin, Imperial College London (United Kingdom)
Guang-Zhong Yang, Imperial College London (United Kingdom)
Daniel S. Elson, Imperial College London (United Kingdom)

Published in SPIE Proceedings Vol. 7169:
Advanced Biomedical and Clinical Diagnostic Systems VII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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