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Proceedings Paper

Epithelial cancer detection by oblique-incidence optical spectroscopy
Author(s): Alejandro Garcia-Uribe; Karthik C. Balareddy; Jun Zou; Kenneth K. Wang M.D.; Madeleine Duvic; Lihong V. Wang
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Paper Abstract

This paper presents a study on non-invasive detection of two common epithelial cancers (skin and esophagus) based on oblique incidence diffuse reflectance spectroscopy (OIDRS). An OIDRS measurement system, which combines fiber optics and MEMS technologies, was developed. In our pilot studies, a total number of 137 cases have been measured in-vivo for skin cancer detection and a total number of 20 biopsy samples have been measured ex-vivo for esophageal cancer detection. To automatically differentiate the cancerous cases from benign ones, a statistical software classification program was also developed. An overall classification accuracy of 90% and 100% has been achieved for skin and esophageal cancer classification, respectively.

Paper Details

Date Published: 23 February 2009
PDF: 6 pages
Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71690A (23 February 2009); doi: 10.1117/12.808576
Show Author Affiliations
Alejandro Garcia-Uribe, Texas A&M Univ. (United States)
Karthik C. Balareddy, Texas A&M Univ. (United States)
Jun Zou, Texas A&M Univ. (United States)
Kenneth K. Wang M.D., Mayo Clinic (United States)
Madeleine Duvic, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 7169:
Advanced Biomedical and Clinical Diagnostic Systems VII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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