
Proceedings Paper
Resolution improvement of the molecular imaging technique based on magnetic nanoparticlesFormat | Member Price | Non-Member Price |
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Paper Abstract
Magnetic particle imaging (MPI) based on the nonlinear interaction between internally administered magnetic
nanoparticles and electromagnetic waves that externally irradiate the body has attracted attention for the early diagnosis
of diseases such as cancer. In MPI, the local magnetic field distribution is scanned, and the magnetization signals are
detected from the magnetic nanoparticles inside a target region. However, interference of the magnetization signals
generated from the magnetic nanoparticles outside a target region due to nonlinear responses results in the degradation of
image resolution. In this study, we clearly show that the degradation of image resolution is a result of the presence of
even harmonics in the magnetization response of magnetic nanoparticles. We propose a new image reconstruction
method for reducing these even harmonics and a correction method for suppressing the interference of the signals. This is
achieved by taking into account the difference between the saturated waveform of the magnetization signal detected from
the magnetic nanoparticles outside a target region and that detected from the magnetic nanoparticles inside a target
region. In this study, we perform numerical analyses to prove that the image resolution in the molecular imaging
technique can be improved by using our proposed image reconstruction method, which is based on the abovementioned
ideas. Furthermore, a fundamental system is constructed and the numerical analyses are experimentally validated by
using magnetic nanoparticles with a diameter of ~20 nm.
Paper Details
Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72584I (13 March 2009); doi: 10.1117/12.807335
Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)
PDF: 8 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72584I (13 March 2009); doi: 10.1117/12.807335
Show Author Affiliations
Yasutoshi Ishihara, Nagaoka Univ. of Technology (Japan)
Yusuke Kusayama, Nagaoka Univ. of Technology (Japan)
Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)
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