Share Email Print

Proceedings Paper

Deformability of mice erythrocytes measured by oscillatory optical tweezers
Author(s): Yu-Shan Huang; Chia-lun Yeh; Guan-Bo Liao; Yi-Fan Chen; Ting-Fen Tsai; Arthur Chiou
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

We used one-dimensional oscillatory optical tweezers in a discrete scanning (or jumping) mode to trap and stretch individual mice erythrocytes and measured their deformation as a function of the jumping distance of the oscillatory trapping beam. In general, we observed that the length of the long axis of red blood cells (RBCs) decreased slightly at small jumping distance and then increased after the jumping distance exceeded a threshold value on the order of a few microns, which is consistent with a recent theoretical prediction. The deformability of three types of mice RBCs, namely the wide-type mice (serving as the control group), old mice, and gene knockout mice were measured and compared. Statistical analysis of their deformability reveals that the RBCs of old mice can be distinguished from those of knockout mice even though these two types of mice exhibit many similar aging-like features.

Paper Details

Date Published: 29 August 2008
PDF: 9 pages
Proc. SPIE 7038, Optical Trapping and Optical Micromanipulation V, 703809 (29 August 2008); doi: 10.1117/12.794690
Show Author Affiliations
Yu-Shan Huang, National Yang-Ming Univ. (Taiwan)
Chia-lun Yeh, National Yang-Ming Univ. (Taiwan)
Guan-Bo Liao, National Yang-Ming Univ. (Taiwan)
Yi-Fan Chen, National Yang-Ming Univ. (Taiwan)
Ting-Fen Tsai, National Yang-Ming Univ. (Taiwan)
Arthur Chiou, National Yang-Ming Univ. (Taiwan)

Published in SPIE Proceedings Vol. 7038:
Optical Trapping and Optical Micromanipulation V
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?