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Proceedings Paper

Ultra-high resolution adaptive optics: optical coherence tomography for in vivo imaging of healthy and diseased retinal structures
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Paper Abstract

Ultra-high isotropic resolution imaging of retinal structures was made possible with an adaptive optics system using dual deformable mirrors and a Fourier-domain optical coherence tomography (Fd-OCT) system with correction for longitudinal chromatic aberration. This system was used to image microscopic retinal structures of healthy as well as diseased retinas in vivo. The improved resolution and contrast enhanced visualization of morphological structures in the retina can be clearly seen. The benefits of this instrument are apparent from comparison of new images with those acquired using a previous generation AO-OCT instrument. Big change in the appearance of speckle field (reduction in speckle size) can be observed as well. Additionally, further improvements in volumetric data acquisition and image representation will be discussed. This includes creation of large Field of View (FOV) AO-OCT volume from multiple sub-volumes and its visualization. Also techniques and results of reducing speckle contrast by averaging multiple B-scans will be presented.

Paper Details

Date Published: 11 March 2008
PDF: 9 pages
Proc. SPIE 6844, Ophthalmic Technologies XVIII, 684408 (11 March 2008); doi: 10.1117/12.764115
Show Author Affiliations
Robert J. Zawadzki, Univ. of California Davis (United States)
Yan Zhang, Indiana Univ. (United States)
Steven M. Jones, Lawrence Livermore National Lab. (United States)
Stacey S. Choi, Univ. of California Davis (United States)
Barry Cense, Indiana Univ. (United States)
Julia W. Evans, Univ. of California Davis (United States)
Lawrence Livermore National Lab. (United States)
Donald T. Miller, Indiana Univ. (United States)
Scot S. Olivier, Lawrence Livermore National Lab. (United States)
John S. Werner, Univ. of California Davis (United States)

Published in SPIE Proceedings Vol. 6844:
Ophthalmic Technologies XVIII
Bruce E. Stuck; Fabrice Manns; Per G. Söderberg; Michael Belkin M.D.; Arthur Ho, Editor(s)

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