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Proceedings Paper

Hormonal component of tumor photodynamic therapy response
Author(s): Mladen Korbelik; Soroush Merchant
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Paper Abstract

The involvement of adrenal glucocorticoid hormones in the response of the treatment of solid tumors by photodynamic therapy (PDT) comes from the induction of acute phase response by this modality. This adrenal gland activity is orchestrated through the engagement of the hypothalamic-pituitary-adrenal hormonal axis incited by stress signals emanating from the PDT-treated tumor. Glucocorticoid hormone activity engendered within the context of PDT-induced acute phase response performs multiple important functions; among other involvements they beget acute phase reactant production, systemic neutrophil mobilization, and control the production of inflammation-modulating and immunoregulatory proteins.

Paper Details

Date Published: 18 February 2008
PDF: 8 pages
Proc. SPIE 6857, Biophotonics and Immune Responses III, 685705 (18 February 2008); doi: 10.1117/12.764023
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Research Ctr. (Canada)
Soroush Merchant, British Columbia Cancer Research Ctr. (Canada)

Published in SPIE Proceedings Vol. 6857:
Biophotonics and Immune Responses III
Wei R. Chen, Editor(s)

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