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Proceedings Paper

Thermal damage of tissue during near-infrared laser irradiation with assistance of light-absorbing dye
Author(s): Surya C. Gnyawali; Kelvin Le; Henry Le; James P. Wicksted; Kenneth E. Bartels; Hong Liu; Yichao Chen; Wei R. Chen
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Paper Abstract

The selective photothermal-tissue interaction using dye enhancement has been proven to be effective in minimizing the peripheral normal tissue damage during cancer treatment. It is important that the tissue-thermal damage be analyzed and the damage rate process be estimated before the photothermal-immunotherapy for cancer treatment. In this study, we have used the EMT6 mouse tumor model for the laser-tumor treatment with a simultaneous surface temperature measurement using infrared thermography. The images acquired were processed to obtain the temperature profiles. The saturation temperature and corresponding time of irradiation from the temporal profiles were used to calculate the damage parameter using Arrhenius rate process equation. The damage parameters obtained from six mice were compared. Our results of in vivo study show that the damage analyses agree with the previous in vitro study on skins.

Paper Details

Date Published: 18 February 2008
PDF: 9 pages
Proc. SPIE 6857, Biophotonics and Immune Responses III, 68570O (18 February 2008); doi: 10.1117/12.763970
Show Author Affiliations
Surya C. Gnyawali, Oklahoma State Univ. (United States)
The Ohio State Univ. Medical Ctr. (United States)
Kelvin Le, Univ. of Central Oklahoma (United States)
Henry Le, Univ. of Central Oklahoma (United States)
James P. Wicksted, Oklahoma State Univ. (United States)
Kenneth E. Bartels, Oklahoma State Univ. (United States)
Hong Liu, Univ. of Oklahoma (United States)
Yichao Chen, Univ. of Central Oklahoma (United States)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 6857:
Biophotonics and Immune Responses III
Wei R. Chen, Editor(s)

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