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Proceedings Paper

Optical properties of human tendons characterized by PSOCT and their relation to tendinopathy: a clinical study
Author(s): P. O. Bagnaninchi; D. Churmakov; M. Bonesi; Y. Yang; C. Phelan; N. Maffulli; I. Meglinski; A. El Haj
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Paper Abstract

Polarisation-sensitive optical coherence tomography (PSOCT) is a non destructive technique with great potential for tendinopathy diagnosis. Functional optical assessment can be used in operating theatres to delineate in depth the margin of the non-healthy area, and limit the amount of tissue to be removed. A clinical study of 21 patients has been undertaken to correlate the optical properties of tendons to their clinical conditions. Tendons were scanned ex vivo with a fibre based time domain PSOCT. The beam from a superluminescent diode with a bandwidth of 52nm is sent through a polarizer and a polarizer modulator, and split into a sample and reference arm. After passing through polarization beam splitter, the interferences fringes are detected with two balanced detectors, for horizontal and vertical polarization. Scattering, birefringence and in depth stokes vectors are extracted from the measurements. Direct microstructural variation and changes in scattering properties are correlated with different tendinopathy and presence of scar tissue, which is cross-validated by histology. Lack of tissue organization, detected as the disappearance of the bands of birefringence, is representative of tendon degeneration. Special attention is paid to the difference between crimp patterns of different patient's tendons. As in polarization microscopy, the crimp pattern appears as extinction bands, and is particularly important as its alteration is generally symptomatic and could be used as an early diagnosis. Its optical origin is investigated by varying polarization and scanning conditions.

Paper Details

Date Published: 20 February 2008
PDF: 10 pages
Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 68541C (20 February 2008); doi: 10.1117/12.763156
Show Author Affiliations
P. O. Bagnaninchi, Keele Univ. (United Kingdom)
D. Churmakov, Cranfield Health, Cranfield Univ. (United Kingdom)
M. Bonesi, Cranfield Health, Cranfield Univ. (United Kingdom)
Y. Yang, Keele Univ. (United Kingdom)
C. Phelan, Univ. Hospital of North Staffordshire (United Kingdom)
N. Maffulli, Keele Univ. (United Kingdom)
I. Meglinski, Cranfield Health, Cranfield Univ. (United Kingdom)
A. El Haj, Keele Univ. (United Kingdom)

Published in SPIE Proceedings Vol. 6854:
Optical Interactions with Tissue and Cells XIX
Steven L. Jacques; William P. Roach; Robert J. Thomas, Editor(s)

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