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Proceedings Paper

The role of autofluorescence colonoscopy in diagnosis and management of solitary rectal ulcer syndrome
Author(s): W. Latos; A. Kawczyk-Krupka; A. Ledwon; A. Kosciarz-Grzesiok; A. Misiak; K. Sieron-Stoltny; A. Sieron M.D.
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Paper Abstract

Solitary rectal ulcer syndrome (SRUS) is a chronic disease of the rectum. Although SRUS is a benign condition there are studies which suggest that chronic ischaemia which occurs in the SRUS may lead to "transitional mucosa" that is similar to that adjacent to colorectal carcinomas and adenomas and may lead to colorectal dysplasia and carcinoma development. The exclusion of primary or metastatic malignancy is the most important aim in the differential diagnosis of SRUS. In our study we assess the possibilities of autofluorescence colonoscopy (AFC) in diagnosis and management of SRUS. We performed white light colonoscopy first. The tissue samples were taken for pathological examination. When SRUS was histopathologically confirmed AFC was performed by means of Xillix OncoLIFE. During AFC numerical colour value (NCV) of autofluorescence of SRUS lesions was noted. During 1946 colonoscopies eight persons were diagnosed as having solitary rectal ulcer syndrome. We did not observe autofluorescence increase in case of polipoid and flat ulcer lesions (NCV 0,39-0,67; mean 0,525) and little increase of autofluorescence in case of erythema lesion (NCV- 0,94). SRUS is a rare disorder of the rectum but it causes differential diagnosis problems. The most common reason for incorrect diagnosis are inadequate tissue specimens. AFC allows to reveal subtle areas within the lesions of more intense autofluorescence and localizes the potential cancer-transformating dysplasia. In this way the most representative area with highest risk of pre- or cancerous changes, for biopsy specimen is indicated.

Paper Details

Date Published: 5 March 2008
PDF: 8 pages
Proc. SPIE 6859, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI, 685906 (5 March 2008); doi: 10.1117/12.762314
Show Author Affiliations
W. Latos, Medical Univ. of Silesia (Poland)
A. Kawczyk-Krupka, Medical Univ. of Silesia (Poland)
A. Ledwon, Medical Univ. of Silesia (Poland)
A. Kosciarz-Grzesiok, Medical Univ. of Silesia (Poland)
A. Misiak, Medical Univ. of Silesia (Poland)
K. Sieron-Stoltny, Medical Univ. of Silesia (Poland)
A. Sieron M.D., Medical Univ. of Silesia (Poland)

Published in SPIE Proceedings Vol. 6859:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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