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Proceedings Paper

Raman spectroscopy for optical diagnosis of laryngeal cancer
Author(s): Seng Khoon Teh; Wei Zheng; David P. Lau M.D.; Zhiwei Huang
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Paper Abstract

In this report, the diagnostic ability of near-infrared (NIR) Raman spectroscopy for identifying the malignant tumors from normal tissues in the larynx was studied. A rapid NIR Raman system was utilized. Multivariate statistical techniques were employed to develop effective diagnostic algorithms. Raman spectra in the range of 800-1,800 cm-1 differed significantly between normal and malignant tumor tissues. The diagnostic algorithms can yielded a diagnostic sensitivity of 92.9% and specificity 83.3% for separating malignant tumors from normal laryngeal tissues. NIR Raman spectroscopy with multivariate statistical techniques has a potential for the non-invasive detection of malignant tumors in the larynx.

Paper Details

Date Published: 8 February 2008
PDF: 4 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68421S (8 February 2008); doi: 10.1117/12.761432
Show Author Affiliations
Seng Khoon Teh, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
David P. Lau M.D., Singapore General Hospital (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)

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