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Proceedings Paper

Laparoscopic optical coherence tomographic imaging of human ovarian cancer
Author(s): Lida P. Hariri; Garret T. Bonnema; Kathy Schmidt; Kenneth Hatch M.D.; Molly Brewer M.D.; Jennifer K. Barton
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Paper Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women in the United States. If diagnosed at an early stage, the 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of all cases are diagnosed at the early, localized stage. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 microns) at imaging depths up to 2 mm. Previously, we studied OCT imaging in normal and diseased human ovary ex vivo to determine the features OCT is capable of resolving. Changes in collagen were suggested with several of the images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated specifically for in vivo laparoscopic imaging. The LOCT probe consists of a 38 mm diameter handpiece terminated in an 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar and is capable of obtaining up to 9.5 mm image lengths at 10 micron axial resolution. In this study, we utilize the LOCT probe to image one or both ovaries of 20 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of identifying and/or differentiating normal and neoplastic ovary. To date, we have laparoscopically imaged the ovaries of ten patients successfully with no known complications.

Paper Details

Date Published: 21 February 2008
PDF: 7 pages
Proc. SPIE 6851, Endoscopic Microscopy III, 685107 (21 February 2008); doi: 10.1117/12.760995
Show Author Affiliations
Lida P. Hariri, The Univ. of Arizona (United States)
Garret T. Bonnema, College of Optical Sciences, The Univ. of Arizona (United States)
Kathy Schmidt, The Univ. of Arizona (United States)
Kenneth Hatch M.D., The Univ. of Arizona (United States)
Molly Brewer M.D., The Univ. of Arizona (United States)
Univ. of Connecticut, Farmington (United States)
Jennifer K. Barton, The Univ. of Arizona (United States)
College of Optical Sciences, The Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 6851:
Endoscopic Microscopy III
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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