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Proceedings Paper

Optical stimulation of the cavernous nerves in the rat prostate
Author(s): Nathaniel M. Fried; Gwen A. Lagoda; Nicholas J Scott; Li-Ming Su M.D.; Arthur L. Burnett M.D.
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Paper Abstract

Laser nerve stimulation has recently been studied as an alternative to electrical stimulation in neuroscience. Advantages include non-contact stimulation, improved spatial selectivity, and elimination of electrical stimulation artifacts. This study explores laser stimulation of the rat cavernous nerves, as a potential alternative to electrical nerve mapping during nerve-sparing radical prostatectomy. The cavernous nerves were surgically exposed in a total of 10 male rats. A Thulium fiber laser stimulated the nerves, with a wavelength of 1870 nm, pulse energy of 7.5 mJ, radiant exposure of 1 J/cm2, pulse duration of 2.5 ms, pulse rate of 10 Hz, and 1-mm laser spot diameter, for a stimulation time of 60 s. A significant increase in the intracavernosal pressure was detected upon laser stimulation, with pressure returning to baseline levels after stimulation. This study demonstrates the feasibility of non-contact laser stimulation of the cavernous nerves using near-infrared laser radiation.

Paper Details

Date Published: 8 February 2008
PDF: 6 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684213 (8 February 2008); doi: 10.1117/12.760950
Show Author Affiliations
Nathaniel M. Fried, Univ. of North Carolina at Charlotte (United States)
Gwen A. Lagoda, Johns Hopkins School of Medicine (United States)
Nicholas J Scott, Univ. of North Carolina at Charlotte (United States)
Li-Ming Su M.D., Johns Hopkins School of Medicine (United States)
Arthur L. Burnett M.D., Johns Hopkins School of Medicine (United States)

Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)

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