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Proceedings Paper

Using contrast transfer function to evaluate the effect of motion blur on microscope image quality
Author(s): Marc C. Wood; Xingwei Wang; Bin Zheng; Shibo Li; Wei Chen; Hong Liu
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Paper Abstract

Scanning of microscope slides is an important part of cytogenetic diagnosis. Metaphase chromosomes arranged in a karyotype reveal the nature and severity of cancer and other diseases. Searching for metaphases spreads is a lengthy and tedious process that can benefit from computer aided systems. When slides are searched by such systems in continuous motion, the image quality is reduced. The motion blur is a function of the scan speed, the camera frame rate and sample time, and the level of magnification. In this study, normalized contrast transfer function (CTF) is used to define the amount of image degradation.

Paper Details

Date Published: 18 February 2008
PDF: 8 pages
Proc. SPIE 6857, Biophotonics and Immune Responses III, 68570F (18 February 2008); doi: 10.1117/12.759203
Show Author Affiliations
Marc C. Wood, Univ. of Oklahoma (United States)
Xingwei Wang, Univ. of Oklahoma (United States)
Bin Zheng, Univ. of Pittsburgh (United States)
Shibo Li, Univ. of Oklahoma Health Ctr. (United States)
Wei Chen, Univ. of Central Oklahoma (United States)
Hong Liu, Univ. of Oklahoma (United States)

Published in SPIE Proceedings Vol. 6857:
Biophotonics and Immune Responses III
Wei R. Chen, Editor(s)

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