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Proceedings Paper

Analysis and feasibility of chemical recording using thermosensitive liposomes
Author(s): Maria E. Tanner; Elizabeth A. Vasievich; Jonathan M. Protz
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Paper Abstract

A new generation of inertial measurement technology is being developed enabling a 10-micron particle to be "aware" of its geospatial location and respond to this information. The proposed approach combines an inertially-sensitive nanostructure or nano fluid/structure system with a nano-sized chemical reactor that functions as an analog computer. Originally, a cantilever-controlled valve used to control a first order chemical reaction was proposed. The feasibility of this concept was evaluated, resulting in a device with significant size reductions, comparable gain, and lower bandwidth than current accelerometers. New concepts with additional refinements have been investigated. Buoyancy-driven convection coupled with a chemical recording technique is explored as a possible alternative. Using a micro-track containing regions of different temperatures and thermosensitive liposomes (TSL), a range of accelerations can be recorded and the position determined. Through careful design, TSL can be developed that have unique transition temperatures and each class of TSL will contain a unique DNA sequence that serves as an identifier. Acceleration can be detected through buoyancy-driven convection. As the liposomes travel to regions of warmer temperature, they will release their contents at the recording site, thus documenting the acceleration. This paper will outline the concept and present the feasibility.

Paper Details

Date Published: 2 January 2008
PDF: 11 pages
Proc. SPIE 6799, BioMEMS and Nanotechnology III, 679905 (2 January 2008); doi: 10.1117/12.755957
Show Author Affiliations
Maria E. Tanner, Duke Univ. (United States)
Elizabeth A. Vasievich, Univ. of North Carolina (United States)
Jonathan M. Protz, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 6799:
BioMEMS and Nanotechnology III
Dan V. Nicolau; Derek Abbott; Kourosh Kalantar-Zadeh; Tiziana Di Matteo; Sergey M. Bezrukov, Editor(s)

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