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Proceedings Paper

Plasmonic optical fiber biosensor for small sample volume
Author(s): Mariko Inoue; Mitsunori Kimura; Keita Mitsui; Kotaro Kajikawa
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Paper Abstract

We developed an optical fiber biosensor based on localized surface plasmon resonance in gold nanoparticles. The sensor system enables us to analyze biological molecules in ultra small amount of analytes. In spite of a simple optical setup, the limit of detection of avidin was about 0.09 μg/mL, which was similar to the value previously reported in a standard absorption experiment. Since the sensor probe is made at the endface of the optical fiber, it has following advantages: (1) it is easy to handle, and (2) it is possible to detect a small amounts of samples (<1μL) such as DNA and proteins. Because of the feature (2), it is possible to carry out DNA and protein detection with a sample solution of 100 nL.

Paper Details

Date Published: 28 September 2007
PDF: 8 pages
Proc. SPIE 6642, Plasmonics: Nanoimaging, Nanofabrication, and Their Applications III, 66421C (28 September 2007); doi: 10.1117/12.735530
Show Author Affiliations
Mariko Inoue, Tokyo Institute of Technology (Japan)
Mitsunori Kimura, Tokyo Institute of Technology (Japan)
Keita Mitsui, PRESTO, JST (Japan)
Kotaro Kajikawa, Tokyo Institute of Technology (Japan)

Published in SPIE Proceedings Vol. 6642:
Plasmonics: Nanoimaging, Nanofabrication, and Their Applications III
Satoshi Kawata; Vladimir M. Shalaev; Din-Ping Tsai, Editor(s)

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