Share Email Print

Proceedings Paper

Reconstruction of tissue dynamics in the compressed breast using multiplexed measurements and temporal basis functions
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

In the course of our experiments imaging the compressed breast in conjunction with digital tomosynthesis, we have noted that significant changes in tissue optical properties, on the order of 5%, occur during our imaging protocol. These changes seem to consistent with changes both in total Hemoglobin concentration as well as in oxygen saturation, as was the case for our standalone breast compression study, which made use of reflectance measurements. Simulation experiments show the importance of taking into account the temporal dynamics in the image reconstruction, and demonstrate the possibility of imaging the spatio-temporal dynamics of oxygen saturation and total Hemoglobin in the breast. In the image reconstruction, we make use of spatio-temporal basis functions, specifically a voxel basis for spatial imaging, and a cubic spline basis in time, and we reconstruct the spatio-temporal images using the entire data set simultaneously, making use of both absolute and relative measurements in the cost function. We have modified the sequence of sources used in our imaging acquisition protocol to improve our temporal resolution, and preliminary results are shown for normal subjects.

Paper Details

Date Published: 1 March 2007
PDF: 8 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643413 (1 March 2007); doi: 10.1117/12.708306
Show Author Affiliations
Gregory Boverman, Rensselaer Polytechnic Institute (United States)
Eric L. Miller, Northeastern Univ. (United States)
Dana H. Brooks, Northeastern Univ. (United States)
Qianqian Fang, Massachusetts General Hospital (United States)
S. A. Carp, Massachusetts General Hospital (United States)
J. J. Selb, Massachusetts General Hospital (United States)
David A. Boas, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?