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Proceedings Paper

Quantitative determination of glucose concentration by swept-source spectral interferometry and spectral phase analysis
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Paper Abstract

We report results of a study demonstrating that swept-source spectral interferometry and spectral phase analysis may be applied to determine quantitatively the concentration of glucose in aqueous solutions. The optical system incorporates a frequency swept laser and fiber-based common-path interferometer and provides a compact, stable experimental system. Spectral phase analysis includes a fast Lomb-Scargle algorithm and a multitaper spectral estimation method that allows for time-frequency analysis. The results show highly sensitive and accurate determination of glucose concentration in solutions with 0.54 mM of resolution and 0.999 correlation coefficient. Swept-source spectral interferometry with spectral phase analysis is a promising methodology for further development of a convenient glucose-sensing method with superior sensitive and accuracy.

Paper Details

Date Published: 13 February 2007
PDF: 9 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301W (13 February 2007); doi: 10.1117/12.702315
Show Author Affiliations
Sanghoon Oh, The Univ. of Texas at Austin (United States)
Kirill V. Larin, Univ. of Houston (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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