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Proceedings Paper

Raman spectra of pigmented skin conditions
Author(s): Renata Bitar; Marcelo Moreno; Andréa Oliveira; Sidney Cartaxo; Herculano Martinho; Ana Maria do Espírito Santo; Ivan Dunshee Santos M.D.; Lydia Massako Ferreira; Airton Martin
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Paper Abstract

Melanoma is the most aggressive skin cancer and is invariably fatal if left untreated. Melanoma removal at early stages is almost always curative and therefore early detection is essential. Removal of every pigmented lesion is unacceptable for the patient, especially in the case of multiple skin lesions or lesions localized in cosmetically important parts of the body such as the face because of risk of scarring. The development of a technique to detect these changes in a noninvasive way is therefore crucial for melanoma detection. In this study, we have used FT-Raman Spectroscopy to investigate through PCA analysis the alterations in the molecular structure of 90 skin spectra, being 30 Pigmented Nevi, 30 Primary Melanoma, and 30 Metastasis, for 6 patients. For projection of data, the scores (Principal Components) PC1 to PC3 were calculated. PC1 versus PC3 for the 800 to 1800 cm-1 spectral region. PC1 versus PC2 for the 1200 to 1400 cm-1 spectral region. In both analysis, we could differentiate the three different types of tissues.

Paper Details

Date Published: 6 February 2007
PDF: 9 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301E (6 February 2007); doi: 10.1117/12.702234
Show Author Affiliations
Renata Bitar, Univ. do Vale do Paraíba (Brazil)
Univ. Federal de São Paulo (Brazil)
Marcelo Moreno, Univ. do Vale do Paraíba (Brazil)
Andréa Oliveira, Univ. Federal de São Paulo (Brazil)
Sidney Cartaxo, Univ. Federal de São Paulo (Brazil)
Herculano Martinho, Univ. do Vale do Paraíba (Brazil)
Ana Maria do Espírito Santo, Univ. do Vale do Paraíba (Brazil)
Ivan Dunshee Santos M.D., Univ. Federal de São Paulo (Brazil)
Lydia Massako Ferreira, Univ. Federal de São Paulo (Brazil)
Airton Martin, Univ. do Vale do Paraíba (Brazil)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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