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Proceedings Paper

Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells
Author(s): Christopher Perry; Alexandrine Randriamahefa; Carl Lokko; Whitney Evans; Julian Watkins; Holly Carrell; Natalie King; Darayas Patel
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Paper Abstract

Oleic acid (OA)-Pluronic-coated iron oxide nanoparticles were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Atomic Force Microscopy (AFM). FT-IR confirmed the bonding of oleic acid and Pluronic (surfactant) to the nanoparticles. AFM measurements on these nanoparticles indicated a root mean square (RMS) roughness, a measure of nanoparticle size of (50 ± 20) nm. The efficiency of these functionalized nanoparticles was investigated by loading with 5-Fluorouracil (5-FU) in aqueous solution. AFM measurements were used to characterize modified iron oxide nanoparticles and pancreatic MIA PaCa-2 cells, including size distribution, stability and cellular uptake. Nanoparticles were added to MIA PaCa-2 cells and assayed for their cytotoxic effects after 24 and 48 hours. The outcome of this study demonstrated the effectiveness of oleic acid (OA)-Pluronic-coated iron oxide nanoparticles as a non-toxic drug delivery agent for pancreatic cancer.

Paper Details

Date Published: 19 February 2007
PDF: 9 pages
Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411T (19 February 2007); doi: 10.1117/12.701754
Show Author Affiliations
Christopher Perry, Oakwood College (United States)
Alexandrine Randriamahefa, Oakwood College (United States)
Carl Lokko, Oakwood College (United States)
Whitney Evans, Oakwood College (United States)
Julian Watkins, Oakwood College (United States)
Holly Carrell, Oakwood College (United States)
Natalie King, Oakwood College (United States)
Darayas Patel, Oakwood College (United States)

Published in SPIE Proceedings Vol. 6441:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
Daniel L. Farkas; Robert C. Leif; Dan V. Nicolau, Editor(s)

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