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Proceedings Paper

Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes
Author(s): Dongyul Chai; Gautam Chaudhary; Ron Kurtz M.D.; Tibor Juhasz
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Paper Abstract

The reduced outflow rate caused by the increased resistance through trabecular meshwork (TM) has been thought to be the main reason for elevated intraocular pressure (IOP). It has been demonstrated that femtosecond laser pulses tuned to 1.7 μm wavelength can create the partial thickness channel in the sclera in ex vivo human eyes [1] and aqueous outflow can be increased by these channels in porcine eyes [2]. It was also shown that the outflow rate is reduced over time in ex vivo human eyes [3]. Therefore, the control experiment without laser treatment at the same condition was conducted and showed that outflow was reduced by 1.5 ± 0.8 μl/min at 15mmHg and 1.8 ± 1.0 μl/min at 25mmHg. However, the outflow rate increased by 0.26 μl/min at 15mmHg and 0.15 μl/min at 25mmHg after the partial thickness channel was created, meaning the amount of increased outflow rate might be more than measured considering the outflow reduction in control experiment. We suggest that the femtosecond laser created partial thickness channel can increase the outflow rate and delay the progression of glaucoma.

Paper Details

Date Published: 6 February 2007
PDF: 8 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350O (6 February 2007); doi: 10.1117/12.701416
Show Author Affiliations
Dongyul Chai, Univ. of California/Irvine (United States)
Gautam Chaudhary, Univ. of California/Irvine (United States)
Ron Kurtz M.D., Univ. of California/Irvine (United States)
Tibor Juhasz, Univ. of California/Irvine (United States)

Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)

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