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Proceedings Paper

Design for manufacturablility (DFM) in the life sciences: fluorescence spectroscopy product platform realized with TracePro suite of opto-mechanical design software tools
Author(s): Edward Freniere; Richard Hassler; Eric Heinz; Linda Smith
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Paper Abstract

This paper describes the design-for-manufacture (DFM) process for a multi-channel fluorometer product platform. The multi-disciplinary team eliminated the cost of quality by design, using a formal design method, facilitated by Lambda Research Corporation's suite of TraceProTM suite of optical design software. Development of this platform presented rigorous design challenges - from identifying feasible design alternatives to minimizing the exponential cumulative effect of component quality and quantity to optimizing tolerances to thoroughly documenting the design. The design was highly constrained in terms of cost and the ability of the platform to accommodate a breadth of fluorescence-tagged media. Furthermore, the inherently interdisciplinary nature of developing medical devices required a high level of collaboration between scientists and engineers across the areas of optics, mechanics, materials, biology and clinical chemistry. While fluorescence tag technologies enable very sensitive detection of molecules, the anisotropic nature of fluorescence in both intensity and polarization severely complicate system design. TracePro's fluorescence modeling capability enabled adherence to a methodical design process of (1) testing system design alternatives, (2) evaluating off-the- shelf and custom optical component and fluorophore feasibility, and (3) tolerancing for robustness without the cost and time associated with iterative hardware prototyping.

Paper Details

Date Published: 6 February 2007
PDF: 6 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301U (6 February 2007); doi: 10.1117/12.701002
Show Author Affiliations
Edward Freniere, Lambda Research Corp. (United States)
Richard Hassler, Lambda Research Corp. (United States)
Eric Heinz, Heinz Optical Engineering (United States)
Linda Smith, Lambda Research Corp. (United States)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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