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Proceedings Paper

Development of broadband multi-channel NIRS (near-infrared spectroscopy) imaging system for quantification of spatial distribution of hemoglobin derivatives
Author(s): Dheerendra Kashyap; Nguvenvu Chu; Aditya Apte; BoPing Wang; Hanli Liu
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Paper Abstract

In this study, we report the development of a near infrared broadband, steady-state, multi-channel imaging system to quantify hemodynamic parameters, which is to be used for measuring the rat brain tumors in vivo. The imager was calibrated with laboratory phantoms to eliminate spectral effects of the CCD spectrometers, optical fibers, and multiplexer channels. The calibration procedures also help determine the source strength in order to obtain accurate image reconstructions. A multi-channel, multi-wavelength, spectrally constrained reconstruction algorithm is under development to obtain tomographic maps of concentrations of hemoglobin derivatives and reduced scattering coefficients. The developed imaging system and reconstruction algorithm were validated with dynamic multi-tube phantoms.

Paper Details

Date Published: 13 February 2007
PDF: 8 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64341X (13 February 2007); doi: 10.1117/12.700894
Show Author Affiliations
Dheerendra Kashyap, Univ. of Texas at Arlington (United States)
Nguvenvu Chu, Univ. of Texas at Arlington (United States)
Aditya Apte, Univ. of Texas at Arlington (United States)
BoPing Wang, Univ. of Texas at Arlington (United States)
Hanli Liu, Univ. of Texas at Arlington (United States)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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