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Proceedings Paper

Reconstruction of absorption and fluorescence contrast for scanning time-domain fluorescence mammography
Author(s): Ronny Ziegler; Tim Nielsen; Thomas Koehler; Dirk Grosenick; Oliver Steinkellner; Axel Hagen; Rainer Macdonald; Herbert Rinneberg
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Paper Abstract

We report on the reconstruction of absorption and fluorescence from measured time-domain diffuse reflectance and transmittance of laser and fluorescence radiation. Measurements were taken on slab-like, diffusely scattering and fluorescent phantoms containing fluorescent inhomogeneities, using fs laser pulses (&lgr; = 730 nm) and time correlated single photon counting. The source was scanned across the entrance face of the phantom, and at each source position data were collected in transmission and reflection at various detector positions. These measurements simulate in vivo data that will be obtained employing a scanning, time-domain fluorescence mammograph, where the breast is gently compressed between two parallel glass plates, and source and detector optical fibers scan synchronously at various source-detector offsets, allowing to record laser and fluorescence mammograms. The diffusion equations for the propagation of the laser and fluorescence radiation were solved in frequency domain by the finite element method. Measured time-resolved phantom data were Fourier-transformed to frequency domain prior to image reconstruction. Signal-to-noise ratios were high enough to use several data sets simultaneously in the reconstruction process belonging to various modulation frequencies up to several hundred MHz. To obtain the spatial distribution of the fluorescent contrast agent the Born approximation of the fluorescence diffusion equation was used.

Paper Details

Date Published: 13 February 2007
PDF: 11 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340H (13 February 2007); doi: 10.1117/12.700860
Show Author Affiliations
Ronny Ziegler, Philips Research Europe-Hamburg (Germany)
Tim Nielsen, Philips Research Europe-Hamburg (Germany)
Thomas Koehler, Philips Research Europe-Hamburg (Germany)
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Oliver Steinkellner, Physikalisch-Technische Bundesanstalt (Germany)
Axel Hagen, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Herbert Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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