
Proceedings Paper
Laser stimulation of auditory neurons at high-repetition rateFormat | Member Price | Non-Member Price |
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Paper Abstract
Pulsed, mid-infrared lasers can evoke neural activity from motor as well as sensory neurons in vivo. Lasers allow more selective spatial resolution of stimulation than the conventional electrical stimulation. To date, few studies have examined pulsed, mid-infrared neural stimulation and very little of the available optical parameter
space has been studied. We found that pulse durations as short as 20 ?s elicit a compound action potential from the gerbil cochlea. Moreover, stimulation thresholds are not a function of absolute energy or absolute power deposited. Compound action potential peak-to-peak amplitude remained constant over extended periods
of stimulation. Stimulation occurred up six hours continuously and up to 50 Hz in repetition rate. Single fiber experiments were made using repetition rates of up to 1 kHz. Action potentials occurred 2.5-4 ms after the laser pulse. Maximum rates of discharge were up to 250 action potentials per second. With increasing stimulation rate
(300 Hz), the action potentials did not respond strictly after the light pulse. The results from these experiments
are important for designing the next generation of neuroprostheses, specifically cochlear implants.
Paper Details
Date Published: 21 February 2007
PDF: 7 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350R (21 February 2007); doi: 10.1117/12.700846
Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)
PDF: 7 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350R (21 February 2007); doi: 10.1117/12.700846
Show Author Affiliations
Agnella D. Izzo, Northwestern Univ. (United States)
Feinberg Medical School, Northwestern Univ. (United States)
Philip Littlefield, Feinberg Medical School, Northwestern Univ. (United States)
Joseph T. Walsh Jr., Northwestern Univ. (United States)
Jim Webb, Aculight Corp. (United States)
Feinberg Medical School, Northwestern Univ. (United States)
Philip Littlefield, Feinberg Medical School, Northwestern Univ. (United States)
Joseph T. Walsh Jr., Northwestern Univ. (United States)
Jim Webb, Aculight Corp. (United States)
Heather Ralph, Aculight Corp. (United States)
Mark Bendett, Aculight Corp. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Claus-Peter Richter, Feinberg Medical School, Northwestern Univ. (United States)
Mark Bendett, Aculight Corp. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Claus-Peter Richter, Feinberg Medical School, Northwestern Univ. (United States)
Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)
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