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Proceedings Paper

Visible lesion laser thresholds in Cynomolgus (Macaca fascicularis) retina with a 1064 nm 12-ns pulsed laser
Author(s): Jeffrey W. Oliver; David J. Stolarski; Gary D. Noojin; Harvey M. Hodnett; Michelle L. Imholte; Benjamin A. Rockwell; Semih S. Kumru
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Paper Abstract

A series of experiments in a new animal model for retinal damage, cynomolgus monkeys (Macaca fascicularis), have been conducted to determine the damage threshold for 12.5-nanosecond laser exposures at 1064 nm. These results provide a direct comparison to threshold values obtained in rhesus monkey (Macaca mulatta), which is the model historically used in establishing retinal maximum permissible exposure (MPE) limits. In this study, the irradiance level of a collimated Gaussian laser beam of 2.5 mm diameter at the cornea was randomly varied to produce a rectangular grid of exposures on the retina. Exposures sites were fundoscopically evaluated at post-irradiance intervals of 1 hour and 24 hours. Probit analysis was performed on dose-response data to obtain probability of response curves. The 50% probability of damage (ED50) values for 1 and 24 hours post-exposure are 28.5(22.7-38.4) &mgr;J and 17.0(12.9-21.8) &mgr;J, respectively. These values compare favorably to data obtained with the rhesus model, 28.7(22.3-39.3) &mgr;J and 19.1(13.6-24.4) &mgr;J, suggesting that the cynomolgus monkey may be a suitable replacement for rhesus monkey in photoacoustic minimum visible lesion threshold studies.

Paper Details

Date Published: 21 February 2007
PDF: 12 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350Q (21 February 2007); doi: 10.1117/12.700587
Show Author Affiliations
Jeffrey W. Oliver, Air Force Research Lab. (United States)
David J. Stolarski, Northrop Grumman (United States)
Gary D. Noojin, Northrop Grumman (United States)
Harvey M. Hodnett, Northrop Grumman (United States)
Michelle L. Imholte, Northrop Grumman (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)
Semih S. Kumru, Air Force Research Lab. (United States)

Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)

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