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Proceedings Paper

Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O2 in single red blood cell
Author(s): Huihua Kenny Chiang; Hung-Shiang Ruan; Hung-You Cheng; Tung-Ting Fang
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Paper Abstract

Raman spectroscopy has been shown to have the potential for providing oxygenated ability of erythrocytes. Raman line at 1638 cm-1 has also been reported as one significant oxygenic indicator for erythrocytes. In this research, we develop the Raman spectroscopic monitoring of the bioeffects of Nitroglycerin on hemoglobin oxygen saturation in a single red blood cell (RBC). Nitroglycerin has been frequently used in the management of angina pectoris. Nitroglycerin liberates nitric oxide (NO) to blood vessels. NO is an oxidizer that easily converts hemoglobin to methemoglobin. The conversion may cause the decrease of oxygenated ability of erythrocytes. In this study, we observed the oxidize state of erythrocytes caused by the over dosage of Nitroglycerin. When the dose of Nitroglycerin exceeds 2x10-4 M, the oxygenic state of erythrocytes decreases significantly. The Raman spectroscopic results demonstrate the observation of the bioeffects of Nitroglycerin on hemoglobin.

Paper Details

Date Published: 6 February 2007
PDF: 8 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301A (6 February 2007); doi: 10.1117/12.700380
Show Author Affiliations
Huihua Kenny Chiang, National Yang-Ming Univ. (Taiwan)
Taipei City Hospital (Taiwan)
Hung-Shiang Ruan, National Yang-Ming Univ. (Taiwan)
Hung-You Cheng, National Yang-Ming Univ. (Taiwan)
Tung-Ting Fang, Songshan Armed Forces General Hospital (Taiwan)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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