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Proceedings Paper

Breast cancer detection using phase-contrast diffuse optical tomography
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Paper Abstract

In this report, a phase-contrast diffuse optical tomography system, which can measure the refractive indices of human breast masses in vivo, is described. To investigate the utility of phase-contrast diffuse optical tomography (PCDOT) for differentiation of malignant and benign breast masses in humans, and to compare PCDOT with conventional diffuse optical tomography (DOT) for analysis of breast masses in humans. 35 breast masses were imaged in 33 patients (mean age = 51 years; range 22-80 years) using PCDOT. Images characterizing the tissue refractive index, absorption and scattering of breast masses were obtained with a finite element-based reconstruction algorithm. The accuracies of absorption and scattering images were compared with images of refractive index in light of the pathology results. Absorption and scattering images were unable to accurately discriminate benign from malignant lesions. Malignant lesions tended to have decreased refractive index allowing them to discriminate from benign lesions in most cases. The sensitivity, specificity, false positive value, and overall accuracy for refractive index were 81.8%, 70.8%, 29.2%, and 74.3%, respectively. Overall we show that benign and malignant breast masses in humans demonstrate different refractive index and differences in refractive index properties can be used to discriminate benign from malignant masses in patients with high accuracy. This opens up a new avenue for improved breast cancer detection using NIR diffusing light.

Paper Details

Date Published: 13 February 2007
PDF: 5 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643425 (13 February 2007); doi: 10.1117/12.700279
Show Author Affiliations
Xiaoping Liang, Univ. of Florida (United States)
Qizhi Zhang, Univ. of Florida (United States)
Changqing Li, Univ. of Florida (United States)
Stephen R. Grobmyer, Univ. of Florida (United States)
Laurie L. Fajardo, Univ. of Iowa (United States)
Huabei Jiang, Univ. of Florida (United States)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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