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Proceedings Paper

Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves
Author(s): Mitsuhiro Terakawa; Shunichi Sato; Daizoh Saitoh; Hitoshi Tsuda; Hiroshi Ashida; Hideyuki Okano; Minoru Obara
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Paper Abstract

We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

Paper Details

Date Published: 19 February 2007
PDF: 5 pages
Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 643513 (19 February 2007); doi: 10.1117/12.700215
Show Author Affiliations
Mitsuhiro Terakawa, Keio Univ. (Japan)
Shunichi Sato, National Defense Medical College Research Institute (Japan)
Daizoh Saitoh, National Defense Medical College Research Institute (Japan)
Hitoshi Tsuda, National Defense Medical College (Japan)
Hiroshi Ashida, Medical College Research Institute (Japan)
Hideyuki Okano, Keio Univ., School of Medicine (Japan)
Minoru Obara, Keio Univ. (Japan)

Published in SPIE Proceedings Vol. 6435:
Optical Interactions with Tissue and Cells XVIII
Steven L. Jacques; William P. Roach, Editor(s)

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