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Proceedings Paper

Protein profile study of breast cancer tissues using HPLC-LIF: a pilot study
Author(s): Suraj Menon; Sujatha Raja; K. Kalyan Kumar; Jacob Kurien; B. R. Krishnanand; K. K. Mahato; Sajan D. George; V. B. Kartha; Santhosh Chidangil
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Paper Abstract

Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.

Paper Details

Date Published: 6 February 2007
PDF: 8 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300W (6 February 2007); doi: 10.1117/12.699935
Show Author Affiliations
Suraj Menon, Kasturba Medical College (India)
Sujatha Raja, Kasturba Medical College (India)
K. Kalyan Kumar, Kasturba Medical College (India)
Jacob Kurien, Kasturba Medical College (India)
B. R. Krishnanand, Kasturba Medical College (India)
K. K. Mahato, Kasturba Medical College (India)
Sajan D. George, Kasturba Medical College (India)
V. B. Kartha, Kasturba Medical College (India)
Santhosh Chidangil, Kasturba Medical College (India)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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