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Proceedings Paper

Convergence analysis and preliminary experimental feasibility for MRI-localized region spectroscopy with NIR diffuse optical tomography
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Paper Abstract

NIR tomography image reconstruction can be improved by incorporating spectral constraints and prior spatial information. The convergence of scattering power was studied based on the distribution of projection error with different parameters. The reason that scattering properties are harder to recover than chromophore concentrations was discussed. Using "hard prior" spectral reconstruction, the role of stopping criteria was found to be important. Multiple wavelength simulations were used to choose suitable stopping criteria. Preliminary tests using a wavelength tunable Ti-Sapphire laser shows promise for frequency domain measurements covering a wide range of wavelengths.

Paper Details

Date Published: 27 March 2007
PDF: 8 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64341B (27 March 2007); doi: 10.1117/12.699371
Show Author Affiliations
Jia Wang, Dartmouth College (United States)
Scott Davis, Dartmouth College (United States)
Shudong Jiang, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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