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Proceedings Paper

An inverse Monte-Carlo method for determining tissue optical properties
Author(s): Zheng Ma; Huijuan Zhao; Yukari Tanikawa; Feng Gao
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Paper Abstract

In this paper, a Monte Carlo based model of diffuse reflectance is introduced to retrieve the light absorption and scattering coefficients of multi-layered tissue. The model consists of a forward part and an inverse one. The forward refers to a multi-layered Monte Carlo simulation at a certain source-detector separation, which lead to a time-resolved profile. The inverse one is a fitting procedure based on Levenberg-Marquardt algorithm using forward model in iteration, and the intensity in time bins is fitted. The model was tested with independent Monte Carlo simulations and fiber-optic-based measurement in the deduced absorption and reduced scattering coefficients. Although a high amount of computation time is needed, this model is developed as a verification standard to these investigation methods using diffuse approximation to the transport equation. Furthermore, it is adaptable to the complex fiber-optic probe geometries.

Paper Details

Date Published: 13 February 2007
PDF: 9 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64342C (13 February 2007); doi: 10.1117/12.697932
Show Author Affiliations
Zheng Ma, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Feng Gao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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