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Proceedings Paper

Fluorescence diffuse optical tomography by full time-resolved scheme
Author(s): Feng Gao; Miao Hui; Huijuan Zhao; Yukari Tanikawa; Yukio Yamada
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Paper Abstract

A full time-resolved (TR) scheme that has been previously developed for diffuse optical tomography is extended to time-domain fluorescence diffuse optical tomography regime, based on the finite-element-finite-time-difference diffusion modeling and the Newtown-Raphson inversion method. We validate the proposed methodology using simulated data and demonstrate its capability of simultaneously recovering the fluorescent yield and lifetime, as well as its superiority of improving quantitative accuracy and spatial resolution of reconstruction to the featured-data one. The full time-resolved scheme helps set up the 'gold standard' for evaluating the performance of the other featured-data ones, and is more practically feasible in molecular imaging than in generic diffuse optical tomography due to availability of the difference measuring.

Paper Details

Date Published: 13 February 2007
PDF: 12 pages
Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64342G (13 February 2007);
Show Author Affiliations
Feng Gao, Tianjin Univ. (China)
Miao Hui, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Yukari Tanikawa, National Institute of Advanced Industrial Science and Technology (Japan)
Yukio Yamada, Univ. of Electro-Communications (Japan)

Published in SPIE Proceedings Vol. 6434:
Optical Tomography and Spectroscopy of Tissue VII
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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