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Proceedings Paper

Cone beam computed tomography angiogenesis imaging: preliminary studies
Author(s): David Conover; Ruola Ning; Scott Paoni; Ian Wilson M.D.; Xianghua Lu; Yan Zhang; Bruce Fenton
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Paper Abstract

The purpose of this study is to demonstrate the feasibility of performing cone beam CT angiogenesis imaging (CBCTAI) using a cone beam CT scanner prototype. We have developed a cone beam breast CT imaging technique that is able to detect a ~2 mm tumor in live mice and have expanded the imaging to include visualization of tumor vessels. The CBCT prototype consisted of a modified clinical CT scanner and a flat panel detector. This CBCT scanner prototype was used for a series of preliminary contrast studies with live mice: contrast-to-scan time delay, contrast for tumor vessel enhancement (comparison with histology) and early tumor vessel development imaging. The results of the live mice studies demonstrate that good image quality can be achieved with this prototype demonstrating the feasibility of CBCTAI. Achieving the CBCTAI technique on the cone beam breast CT imaging modality will significantly advance breast cancer detection, diagnosis and treatment.

Paper Details

Date Published: 13 March 2006
PDF: 6 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61433G (13 March 2006); doi: 10.1117/12.655655
Show Author Affiliations
David Conover, Univ. of Rochester Medical Ctr. (United States)
Ruola Ning, Univ. of Rochester Medical Ctr. (United States)
Scott Paoni, Univ. of Rochester (United States)
Ian Wilson M.D., Univ. of Rochester Medical Ctr. (United States)
Xianghua Lu, Univ. of Rochester Medical Ctr. (United States)
Yan Zhang, Univ. of Rochester Medical Ctr. (United States)
Bruce Fenton, Univ. of Rochester (United States)


Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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