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Proceedings Paper

Fully automatic segmentation of left ventricular myocardium in real-time three-dimensional echocardiography
Author(s): Vivek Walimbe; Vladimir Zagrodsky; Raj Shekhar
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Paper Abstract

Purpose: We report a deformable model (DM)-based fully automatic segmentation of the left ventricular (LV) myocardium (endocardium + epicardium) in real-time three-dimensional (3D) echocardiography. Methods: Initialization of the DM is performed through automated mutual information-based registration of the image to be segmented with a 3D template (image + corresponding endo-epicardial wiremesh). The initialized endocardial and epicardial wiremesh templates are then simultaneously refined iteratively under the joint influence of mesh-derived internal forces, image-derived external (gradient vector flow-based) forces, and endo-epicardium mesh-interaction forces. Incorporation of adaptive mesh-interaction forces into the DM refinement, a novelty of the current work, ensures appropriate relative endo-epicardial orientation during simultaneous refinement. Repeating for the entire cardiac sequence provides the segmented myocardium for all phases. Preliminary comparison is presented between automatic and expert-defined myocardial segmentation for five subjects imaged in clinical settings using a Philips SONOS 7500 scanner. Results: Root mean square (rms) radial distance error between the algorithm-determined and expert-traced endocardial and epicardial contours in six predetermined planar views was 3.86 ± 0.72 mm and 4.0 ± 0.63 mm in end-diastole, 3.9 ± 0.51 mm and 4.04 ± 0.65 mm in systole, respectively. Mean absolute error between average myocardial thickness calculated using automatic and expert-defined contours was 1.64 ± 0.56 mm (apical), 1.3 ± 0.58 mm (mid) and 1.46 ± 0.45 mm (basal). The absolute difference in ejection fraction calculated using our algorithm and by the expert using the TomTec software was 7.2 ± 0.84 %. Conclusion: We demonstrate successful segmentation of LV myocardium, which allows clinically important LV structure and function (e.g. wall thickness, LV volume and ejection fraction) to be tracked over the entire cardiac cycle.

Paper Details

Date Published: 16 March 2006
PDF: 10 pages
Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61444H (16 March 2006); doi: 10.1117/12.654050
Show Author Affiliations
Vivek Walimbe, The Ohio State Univ. (United States)
Lerner Research Institute, Cleveland Clinic (United States)
Vladimir Zagrodsky, Lerner Research Institute, Cleveland Clinic (United States)
Raj Shekhar, Univ. of Maryland, Baltimore (United States)

Published in SPIE Proceedings Vol. 6144:
Medical Imaging 2006: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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