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Proceedings Paper

Airway morphometry in the lungs as depicted in chest CT examinations variability of measurements
Author(s): J. Ken Leader; Bin Zheng; Frank C. Scuirba; Harvey O. Coxson; Joel L. Weissfeld; Carl R. Fuhrman; Glenn S. Maitz; David Gur
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Paper Abstract

The purpose of the study was to decrease the variability of computed tomographic airway measurements. We to developed and evaluated a novel computer scheme to automatically segment airways depicted on chest CT examinations at the level of the lobar and segmental bronchi and to decrease. The computer scheme begins with manual selection of a seed point within the airway from which the airway wall and lumen are automatically segmented and airway pixels were assigned full or partial membership to the lumen or wall. Airway pixels not assigned full membership to the lumen (< -900 HU) or wall (> 0 HU) were assigned partial membership to the lumen and wall. In fifteen subjects with no visible signs of emphysema and a range of pulmonary obstruction from none to severe, airway measures were compared to pulmonary function parameters in a rank order analysis to evaluate measuring a single airway versus multiple airways. The quality of the automated airway segmentation was visually acceptable. The Pearson Correlation coefficients for the ranking of FEV1 versus wall area percent (percent of total airway size) and FVC versus wall area percent were 0.164 and 0.175 for a single measurement, respectively, and were 0.243 and 0.239 for multiple measurements, respectively. Our preliminary results suggest that averaging the measurements from multiple airways may improve the relation between airway measures and lung function compared to measurement from a single airway, which improve quantification of airway remodeling in COPD patients.

Paper Details

Date Published: 13 March 2006
PDF: 9 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61432R (13 March 2006); doi: 10.1117/12.653984
Show Author Affiliations
J. Ken Leader, Univ. of Pittsburgh (United States)
Bin Zheng, Univ. of Pittsburgh (United States)
Frank C. Scuirba, Univ. of Pittsburgh (United States)
Harvey O. Coxson, Vancouver General Hospital (Canada)
Joel L. Weissfeld, Univ. of Pittsburgh (United States)
Carl R. Fuhrman, Univ. of Pittsburgh (United States)
Glenn S. Maitz, Univ. of Pittsburgh (United States)
David Gur, Univ. of Pittsburgh (United States)

Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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