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Proceedings Paper

Towards a patient-specific modeling II: biomechanics of a growing aneurysm
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Paper Abstract

Recent advances in medical imaging, computational methods, and biomechanics hold great promise for engineering-based decision making in clinical practice. Towards patient-specific modeling, however, we need to synthesize better the separate advances in computational biofluid mechanics and arterial wall mechanics. In this paper, we propose a mathematical model of growing fusiform aneurysms that is able to test multiple competing hypotheses with regard to the production, removal, and organization of intramural collagen, and thus to predict their consequences in enlargement and changes in material properties of the lesion. To apply this model to realistic cases, including fluid-solid interactions, we also need to develop a method to exploit current advances in computational biofluid mechanics. Thus, we describe a method to represent highly nonlinear and anisotropic material behaviors within a linearized constitutive equation commonly employed in fluid-structure simulations of blood flow in deformable arteries.

Paper Details

Date Published: 13 March 2006
PDF: 6 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61432C (13 March 2006); doi: 10.1117/12.653899
Show Author Affiliations
Seungik Baek, Texas A&M Univ. (United States)
C. Alberto Figueroa, Stanford Univ. (United States)
Charles A. Taylor, Stanford Univ. (United States)
Jay D. Humphrey, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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