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Proceedings Paper

Quantification of tumor mobility during the breathing cycle using 3D dynamic MRI
Author(s): Max Schoebinger; Christian Plathow; Ivo Wolf; Hans-Ulrich Kauczor; Hans-Peter Meinzer
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Paper Abstract

Respiration causes movement and shape changes in thoracic tumors, which has a direct influence on the radio-therapy planning process. Current methods for the estimation of tumor mobility are either two-dimensional (fluoroscopy, 2D dynamic MRI) or based on radiation (3D (+t) CT, implanted gold markers). With current advances in dynamic MRI acquisition, 3D+t image sequences of the thorax can be acquired covering the thorax over the whole breathing cycle. In this work, methods are presented for the interactive segmentation of tumors in dynamic images, the calculation of tumor trajectories, dynamic tumor volumetry and dynamic tumor rotation/deformation based on 3D dynamic MRI. For volumetry calculation, a set of 21 related partial volume correcting volumetry algorithms has been evaluated based on tumor surrogates. Conventional volumetry based on voxel counting yielded a root mean square error of 29% compared to a root mean square error of 11% achieved by the algorithm performing best among the different volumetry methods. The new workflow has been applied to a set of 26 patients. Preliminary results indicate, that 3D dynamic MRI reveals important aspects of tumor behavior during the breathing cycle. This might imply the possibility to further improve high-precision radiotherapy techniques.

Paper Details

Date Published: 13 March 2006
PDF: 8 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61430P (13 March 2006); doi: 10.1117/12.653153
Show Author Affiliations
Max Schoebinger, German Cancer Research Ctr. (Germany)
Christian Plathow, German Cancer Research Ctr. (Germany)
Ivo Wolf, German Cancer Research Ctr. (Germany)
Hans-Ulrich Kauczor, German Cancer Research Ctr. (Germany)
Hans-Peter Meinzer, German Cancer Research Ctr. (Germany)

Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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