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Proceedings Paper

Non-rigid registration for fusion of carotid vascular ultrasound and MRI volumetric datasets
Author(s): R. C. Chan; S. Sokka; D. Hinton; R. Manzke; A. Hanekamp; V. Y. Reddy; M. R. Kaazempur-Mofrad; V. Rasche
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Paper Abstract

In carotid plaque imaging, MRI provides exquisite soft-tissue characterization, but lacks the temporal resolution for tissue strain imaging that real-time 3D ultrasound (3DUS) can provide. On the other hand, real-time 3DUS currently lacks the spatial resolution of carotid MRI. Non-rigid alignment of ultrasound and MRI data is essential for integrating complementary morphology and biomechanical information for carotid vascular assessment. We assessed non-rigid registration for fusion of 3DUS and MRI carotid data based on deformable models which are warped to maximize voxel similarity. We performed validation in vitro using isolated carotid artery imaging. These samples were subjected to soft-tissue deformations during 3DUS and were imaged in a static configuration with standard MR carotid pulse sequences. Registration of the source ultrasound sequences to the target MR volume was performed and the mean absolute distance between fiducials within the ultrasound and MR datasets was measured to determine inter-modality alignment quality. Our results indicate that registration errors on the order of 1mm are possible in vitro despite the low-resolution of current generation 3DUS transducers. Registration performance should be further improved with the use of higher frequency 3DUS prototypes and efforts are underway to test those probes for in vivo 3DUS carotid imaging.

Paper Details

Date Published: 10 March 2006
PDF: 8 pages
Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61442E (10 March 2006); doi: 10.1117/12.651786
Show Author Affiliations
R. C. Chan, Philips Research North America (United States)
S. Sokka, Philips Research North America (United States)
D. Hinton, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
R. Manzke, Philips Research North America (United States)
A. Hanekamp, Philips Research North America (United States)
V. Y. Reddy, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
M. R. Kaazempur-Mofrad, Univ. of California/Berkeley (United States)
V. Rasche, Univ. of Ulm (Germany)

Published in SPIE Proceedings Vol. 6144:
Medical Imaging 2006: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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