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Proceedings Paper

Regional gray matter abnormalities in patients with schizophrenia determined with optimized voxel-based morphometry
Author(s): XiaoJuan Guo; Li Yao; Zhen Jin; Kewei Chen
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Paper Abstract

This study examined regional gray matter abnormalities across the whole brain in 19 patients with schizophrenia (12 males and 7 females), comparing with 11 normal volunteers (7 males and 4 females). The customized brain templates were created in order to improve spatial normalization and segmentation. Then automated preprocessing of magnetic resonance imaging (MRI) data was conducted using optimized voxel-based morphometry (VBM). The statistical voxel based analysis was implemented in terms of two-sample t-test model. Compared with normal controls, regional gray matter concentration in patients with schizophrenia was significantly reduced in the bilateral superior temporal gyrus, bilateral middle frontal and inferior frontal gyrus, right insula, precentral and parahippocampal areas, left thalamus and hypothalamus as well as, however, significant increases in gray matter concentration were not observed across the whole brain in the patients. This study confirms and extends some earlier findings on gray matter abnormalities in schizophrenic patients. Previous behavior and fMRI researches on schizophrenia have suggested that cognitive capacity decreased and self-conscious weakened in schizophrenic patients. These regional gray matter abnormalities determined through structural MRI with optimized VBM may be potential anatomic underpinnings of schizophrenia.

Paper Details

Date Published: 13 March 2006
PDF: 7 pages
Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431Y (13 March 2006); doi: 10.1117/12.651558
Show Author Affiliations
XiaoJuan Guo, Beijing Normal Univ. (China)
Li Yao, Beijing Normal Univ. (China)
Zhen Jin, Beijing 306 Hospital (China)
Kewei Chen, Banner Good Samaritan Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 6143:
Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Armando Manduca; Amir A. Amini, Editor(s)

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