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Proceedings Paper

Weighted medical image registration with automatic mask generation
Author(s): Hanno Schumacher; Astrid Franz; Bernd Fischer
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Paper Abstract

Registration of images is a crucial part of many medical imaging tasks. The problem is to find a transformation which aligns two given images. The resulting displacement fields may be for example described as a linear combination of pre-selected basis functions (parametric approach), or, as in our case, they may be computed as the solution of an associated partial differential equation (non-parametric approach). Here, the underlying functional consists of a smoothness term ensuring that the transformation is anatomically meaningful and a distance term describing the similarity between the two images. To be successful, the registration scheme has to be tuned for the problem under consideration. One way of incorporating user knowledge is the employment of weighting masks into the distance measure, and thereby enhancing or hiding dedicated image parts. In general, these masks are based on a given segmentation of both images. We present a method which generates a weighting mask for the second image, given the mask for the first image. The scheme is based on active contours and makes use of a gradient vector flow method. As an example application, we consider the registration of abdominal computer tomography (CT) images used for radiation therapy. The reference image is acquired well ahead of time and is used for setting up the radiation plan. The second image is taken just before the treatment and its processing is time-critical. We show that the proposed automatic mask generation scheme yields similar results as compared to the approach based on a pre-segmentation of both images. Hence for time-critical applications, as intra-surgery registration, we are able to significantly speed up the computation by avoiding a pre-segmentation of the second image.

Paper Details

Date Published: 10 March 2006
PDF: 8 pages
Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61442B (10 March 2006); doi: 10.1117/12.651323
Show Author Affiliations
Hanno Schumacher, Univ. of Lübeck (Germany)
Astrid Franz, Philips Research Labs. (Germany)
Bernd Fischer, Univ. of Lübeck (Germany)

Published in SPIE Proceedings Vol. 6144:
Medical Imaging 2006: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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