
Proceedings Paper
Two-distance partial pathlength method for accurate measurement of muscle oxidative metabolism using fNIRSFormat | Member Price | Non-Member Price |
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Paper Abstract
Near infrared spectroscopy (NIRS) is now a commonly accepted method
for the measurement of oxidative metabolism of brain and muscle
tissues. Nevertheless, this technology suffers from the error caused
by the homogeneous single layer assumption in the calculations of
concentration changes of light absorber chromophores using either
diffusion theory or modified Beer-Lambert law. Underestimation of
muscle oxidative metabolism for muscles having thicker fat layer
above is a particular case. Due to this uncertainty, statistical
analysis can be problematic in reviewing the results across subjects
having different fat thicknesses for muscle studies. In this study, partial pathlength method with two detectors based on modified
Beer-Lambert law extended for heterogeneous medium with homogeneous
layered regions is investigated. Using Monte Carlo simulations,
comparison between this technique and single homogeneous layer
assumption is done. Optical coefficients of fat and muscle layers
are chosen typical for muscle tissue measurements. In the
simulations, change of absorption coefficient in muscle layer was
made much bigger than in fat layer. It has been found that for
2-detector partial pathlength based method, fat and muscle layer
absorption coefficient change estimates are better than the
homogeneous medium based modified Beer-Lambert law estimates in all
simulated cases.
Paper Details
Date Published: 1 March 2006
PDF: 8 pages
Proc. SPIE 6084, Optical Interactions with Tissue and Cells XVII, 60840O (1 March 2006); doi: 10.1117/12.644603
Published in SPIE Proceedings Vol. 6084:
Optical Interactions with Tissue and Cells XVII
Steven L. Jacques; William P. Roach, Editor(s)
PDF: 8 pages
Proc. SPIE 6084, Optical Interactions with Tissue and Cells XVII, 60840O (1 March 2006); doi: 10.1117/12.644603
Show Author Affiliations
Ömer Şayli, Boğaziçi Univ. (Turkey)
Ata Akın, Boğaziçi Univ. (Turkey)
Published in SPIE Proceedings Vol. 6084:
Optical Interactions with Tissue and Cells XVII
Steven L. Jacques; William P. Roach, Editor(s)
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