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Proceedings Paper

A CMOS active pixel sensor for retinal stimulation
Author(s): Mark L. Prydderch; Marcus J. French; Keith Mathieson; Christopher Adams; Deborah Gunning; Jonathan Laudanski; James D. Morrison; Alan R. Moodie; James Sinclair
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Paper Abstract

Degenerative photoreceptor diseases, such as age-related macular degeneration and retinitis pigmentosa, are the most common causes of blindness in the western world. A potential cure is to use a microelectronic retinal prosthesis to provide electrical stimulation to the remaining healthy retinal cells. We describe a prototype CMOS Active Pixel Sensor capable of detecting a visual scene and translating it into a train of electrical pulses for stimulation of the retina. The sensor consists of a 10 x 10 array of 100 micron square pixels fabricated on a 0.35 micron CMOS process. Light incident upon each pixel is converted into output current pulse trains with a frequency related to the light intensity. These outputs are connected to a biocompatible microelectrode array for contact to the retinal cells. The flexible design allows experimentation with signal amplitudes and frequencies in order to determine the most appropriate stimulus for the retina. Neural processing in the retina can be studied by using the sensor in conjunction with a Field Programmable Gate Array (FPGA) programmed to behave as a neural network. The sensor has been integrated into a test system designed for studying retinal response. We present the most recent results obtained from this sensor.

Paper Details

Date Published: 6 February 2006
PDF: 9 pages
Proc. SPIE 6068, Sensors, Cameras, and Systems for Scientific/Industrial Applications VII, 606803 (6 February 2006); doi: 10.1117/12.641165
Show Author Affiliations
Mark L. Prydderch, Rutherford Appleton Lab. (United Kingdom)
Marcus J. French, Rutherford Appleton Lab. (United Kingdom)
Keith Mathieson, Univ. of Glasgow (United Kingdom)
Christopher Adams, Univ. of Glasgow (United Kingdom)
Deborah Gunning, Univ. of Glasgow (United Kingdom)
Jonathan Laudanski, Univ. of Glasgow (United Kingdom)
James D. Morrison, Univ. of Glasgow (United Kingdom)
Alan R. Moodie, Univ. of Glasgow (United Kingdom)
James Sinclair, Univ. of Glasgow (United Kingdom)

Published in SPIE Proceedings Vol. 6068:
Sensors, Cameras, and Systems for Scientific/Industrial Applications VII
Morley M. Blouke, Editor(s)

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