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Proceedings Paper

The potential of vibrational spectroscopy in the early detection of cervical cancer: an exciting emerging field
Author(s): Eoghan O Faolain; Mary B. Hunter; Joe M. Byrne; Peter Kelehan; Hugh J. Byrne; Fiona M. Lyng
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Paper Abstract

The application of vibrational spectroscopy to disease diagnosis is a relatively new, rapidly evolving scientific field. Techniques such as Raman and infrared spectroscopy have shown great promise in this regard over the past number of years. This study directly compared Raman spectroscopy and synchrotron infrared (SR-IR) spectroscopy on parallel cervical cancer samples. Both frozen and dewaxed formalin fixed paraffin preserved tissue sections were examined. Both tissue types produced good quality Raman and SR-IR spectra, although the lesser processed, frozen tissue sections displayed the most detailed spectra. Spectroscopy was shown capable of discriminating between different cell types in normal cervical tissue. Spectra recorded from invasive carcinoma showed a marked difference from those recorded from normal cervical epithelial cells. Spectral differences identified with the onset of carcinogenesis include increased nucleic acid contributions and decreased glycogen levels. These investigations pave the way for an enlarged study into this exciting new diagnostic field.

Paper Details

Date Published: 3 June 2005
PDF: 12 pages
Proc. SPIE 5826, Opto-Ireland 2005: Optical Sensing and Spectroscopy, (3 June 2005); doi: 10.1117/12.603344
Show Author Affiliations
Eoghan O Faolain, Dublin Institute of Technology (Ireland)
Mary B. Hunter, National Maternity Hospital (Ireland)
Joe M. Byrne, National Maternity Hospital (Ireland)
Peter Kelehan, National Maternity Hospital (Ireland)
Hugh J. Byrne, Dublin Institute of Technology (Ireland)
Fiona M. Lyng, Dublin Institute of Technology (Ireland)

Published in SPIE Proceedings Vol. 5826:
Opto-Ireland 2005: Optical Sensing and Spectroscopy
Gerard D. O'Sullivan; Brian D. MacCraith; Hugh James Byrne; Enda McGlynn; Alan G. Ryder, Editor(s)

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