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Proceedings Paper

Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies
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Paper Abstract

An in vivo shell-less chick chorioallantoic membrane (CAM) brain tumor model has been developed to investigate the effects of photodynamic therapy (PDT) and anti-antiogenic treatments. Multicellular human glioma spheroids were placed on the CAM at day 7 of embryonic development. Angiogenesis was observed four days post implantation. Significant damage to the CAM vasculature was observed immediately following 5-aminolevulinic acid (ALA) mediated PDT.

Paper Details

Date Published: 25 April 2005
PDF: 6 pages
Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); doi: 10.1117/12.596910
Show Author Affiliations
Nzola De Magalhaes, Beckman Laser Institute, Univ. of California/Irvine (United States)
Chung-Ho Sun, Beckman Laser Institute, Univ. of California/Irvine (United States)
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Univ. of Nevada/Las Vegas Cancer Research Ctr. (United States)
Henry Hirschberg, Beckman Laser Institute, Univ. of California/Irvine (United States)
Rikshospitalet (Norway)
Bruce J. Tromberg, Beckman Laser Institute, Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 5686:
Photonic Therapeutics and Diagnostics
Brian Jet-Fei Wong M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Reza S. Malek M.D.; Henry Hirschberg M.D.; Kenneth Eugene Bartels D.V.M.; Steen J. Madsen; Lloyd P. Tate V.D.M.; Lawrence S. Bass M.D.; Werner T. W. de Riese; Karen M. McNally-Heintzelman, Editor(s)

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